Iowa State University’s Department of Chemical and Biological Engineering researchers are leading two of five new projects announced by BioMADE to advance the United States bioeconomy and biomanufacturing goals. These projects were funded through a special BioMADE Project Call on advancing bioreactor design and development thanks to support from Schmidt Futures. They aim to use innovative technologies in bioreactor hardware, software, sensors, modeling, and automation to produce biobased products more efficiently at a commercial scale.